Kaplan and Sadock's Chapter 13 & 26 from Study Guide

Kaplan and
Sadock's
Chapter 13 &
26 from Study
Guide
13.1. Which of the following statements about the
dopamine hypothesis of schizophrenia is true?
A. Dysregulation of dopaminergic
neurotransmission is caused by postsynaptic
sensitivity.
B. Dopamine release caused by amphetamine
challenge is higher during remission.
C. Higher amphetamine-provoked dopamine
release predicts worsening of psychotic symptoms.
D. Overactivity of dopamine in the subcortical basal
ganglia contributes to negative symptoms.
E. There is a lower occupancy of D2/3 receptors in
relapsed patients. - ANSWER-C. Higher
amphetamine-provoked dopamine release predicts
worsening of psychotic symptoms.
13.2. True statements about hypothesized
neurobiological models of schizophrenia include
A. Genes function in part by increasing vulnerability
to environmental factors.
B. Environmental factors increase risk by producing
subtle brain damage.
C. The apparent lack of gliosis in postmortem
studies implicates in utero factors.
D. As the prefrontal cortex matures, behavioral and
cognitive sequelae of subtle structural deficits
become manifest.
E. All of the above - ANSWER-E. All of the above
13.3. With regard to the ventricular size in
schizophrenia, which of the following statements is
true?
A. Patients with schizophrenia invariably
demonstrate significant enlargement of the fourth
ventricle only.
B. Ventricular enlargement is a pathognomonic
finding in schizophrenia.
C. Ventricular changes in schizophrenia are likely to
be specific for the pathophysiological processes
underlying this disorder.
D. All of the above
E. None of the above - ANSWER-E. None of the
above
13.4. All of the following lead to an increased risk of
schizophrenia except
A. having a deviant course of personality
maturation and development
B. having previously attempted suicide
C. having a schizophrenic family member
D. having a history of temporal lobe epilepsy
E. having low levels of monoamine oxidase, type B,
in blood platelets - ANSWER-B. having previously
attempted suicide
13.5. True statements about violence and
schizophrenia include all of the following except
A. Violence in a hospital setting can result from
undiagnosed neuroleptic-induced acute akathisia.
B. Patients with schizophrenia are more violent as a
group than the general population.
C. It is more difficult to prevent most schizophrenic
homicides compared with the general population.
D. Patients with disorganized schizophrenia are at
much greater risk to commit violence than those
with paranoid schizophrenia.
E. Command hallucinations do not appear to play a
particularly important role in violence. - ANSWER-D.
Patients with disorganized schizophrenia are at
much greater risk to commit violence than those
with paranoid schizophrenia.