Cellular and Molecular Immunology 9th Edition Abbas Test Bank Latest Updates 2023 A+ GRADE.

Cellular and Molecular Immunology 9th
Edition Abbas Test Bank Latest Updates
2023 A+ GRADE.
Abbas: Cellular and Molecular Immunology, 9th Edition
Antibodies and Antigens
Test Bank
Matching
Questions 1-5
Match each of the descriptions in questions 1-5 with the correct lettered antibody isotype
(A-E). (Answers may be used more than once.)
A. IgA
B. IgD
C. IgE
D. IgG
E. IgM
1. The secreted form of this isotype forms pentamers around a J chain
ANS: E. IgM is secreted as a J chain–linked pentamer.
2. The most abundant Ig isotype in the blood
ANS: D. The blood IgG concentration is about 3.5mg/ml and includes four subtypes
(IgG1 to IgG4).
3. The isotype only found in membrane-bound form on naive B cells
ANS: B. Very little IgD is secreted, and in membrane form is only on the surface of naive
B cells. Its function is not well understood.
4. The isotype found predominantly in mucosal secretions
ANS: A. IgA accounts for almost two thirds of the 3 g of antibody produced each day by
an adult, most of which is produced in the gastrointestinal associated lymphoid tissues and
secreted into the gut lumen.
5. The isotype most closely associated with immediate hypersensitivity (allergic) disease
ANS: C. Most IgE that is secreted is bound to mast cells, and it plays a role in the activation
of mast cells during allergic reactions.
Questions 6-10
Match each description in questions 6-10 with the appropriate lettered term (A-I).
A. Conformational determinant
Test Bank 2
B. Linear determinant
C. Neoantigenic determinant
D. Hinge region
E. Immun complex
F. Fab
G. Fc
H. Tail piece
I. Hapten
6. A proteolytic fragment of an antibody molecule that contains an intact antigen- binding
site
ANS: F. Fab fragments, derived from enzymatic cleavage of Ig molecules, are composed
of one intact light chain covalently linked to the N-terminal region of one heavy chain and
include a single intact antigen-binding site.
7. A three-dimensional shape, formed by a portion of a macromolecule, to which an
antibody binds
ANS: A. Conformational determinants will usually be destroyed by physicochemical
disruption of macromolecules, such as by denaturation or proteolysis of proteins.
8. A small chemical group recognized by an antibody that is attached to a larger
macromolecule
ANS: I. Although haptens can be recognized by antibodies, they are not, by themselves,
able to stimulate an antibody response (i.e., they are not immunogens). Antibody responses
to haptens can be induced when the hapten is attached to a macromolecule, called a carrier.
9. The proteolytic fragment of an antibody molecule that contains the heavy chain
constant region
ANS: G. The Fc fragment, generated by proteolytic cleavage of an antibody molecule, is
composed of the C-terminal end of the heavy chain and lacks the antigen-binding region.
This region of an intact Ig molecule, which can interact with Ig receptors and complement,
is called the Fc region.
10. A region of an antibody molecule that permits bivalent binding of antibodies to pairs
of surface epitopes varying in distance from one another
ANS: D. The hinge region, locat