What is the strongest established risk factor for bipolar disorder? Family History
Response Feedback:
“The strongest established risk factor for BPD is a family history of BPD.”
Which of the following medications are known as selective serotonin re-uptake inhibitors (SSRIs)?
i. Nortriptyline
ii. Citalopram
iii. Duloxetine
iv. Fluoxetine
v. Venlafaxine
Which disease state of a non-adherent patient is at greater risk for substance use, violence, and victimization as well as worse overall quality of life? Schizophrenia
Response Feedback:
“Moreover, non-adherent patients with schizophrenia are at greater risk for substance use, violence, and victimization as well as worse overall quality of life.”
Patient is a 72-year-old male with a past medical history significant for atrial fibrillation and COPD with a new diagnosis of major depression disorder. Based on his comorbid
conditions, what antidepressant would you recommend as first-line?
Response Feedback:
(Options C & D are both TCA antidepressants and, based on the patient’s age and comorbid conditions, a TCA would likely result in more side effects, such as increased fall risk due to potential for orthostatic hypotension and anticholinergic-related side effects. In addition, patient has a history for cardiac abnormalities due to A. fib diagnosis - TCAs result in electrocardiographic changes in susceptible individuals, therefore, would likely avoid. Choice B is used more for ADHD purposes than as an antidepressant)
Page numbers used: Page 39 for TCA side-effect profile
Which of the following is an appropriate strategy for managing treatment-resistant depression?
Use both SSRI and SNRI
Which of the following medications is best to AVOID in maintenance treatment of bipolar disorder and why?
Response Feedback:
“As noted previously, antidepressants may contribute to an increase in mood episode frequency.”
With second-generation antipsychotics, what is the main side effect that requires frequent monitoring?
Response Feedback:
table 7-6 & page 80, table 7-7; Page 78: “However, attention over the past decade has focused on effect of second-generation antipsychotics on glucose metabolism and lipids and associated metabolic syndrome.”
Which amino acid is involved in the synthesis of both norepinephrine and dopamine?
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