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NR 546 Week 3 Assignment; Antipsychotic Medications Table: (Solved) Guaranteed A+ Guide

NR 546 Week 3 Assignment; Antipsychotic Medications Table: (Solved) Guaranteed A+ Guide

Drug name Indication
Target symptoms: state if positive or negative effect
Potency (if noted. receptor occupancy if noted )
Neurotransmitter(s) affected
Half-life
(T1/2),
metabolism
(CYP 450
enzyme)
Notable side effects (associate to pathway or NT)
Typical antipsychotics (conventional)
Haloperidol Dopamine Receptor Antagonist
Targets the symptoms of psychosis such as hallucinations
and delusions. It can also be used to treat the tics and
vocalizations of Tourette’s, as a second-line treatment for
hyperactivity and severe behavioral problems in children.
Works by blocking D2 receptors to reduce the positive
symptoms of psychosis as well as possibly decreasing
combative, explosive, and hyperactive behaviors. Its use
in Tourette’s is related to blocking D2 receptors in the
nigrostriatal pathway.
Single dose:
12-38 hours
Chronic use:
21 days
Substrate
CYP450 2D6
● Akathisia, dystonia, and drug-induced
parkinsonism- linked to blockade of D2
receptors in the striatum
● Tardive dyskinesia- linked to chronic
blockade of D2 receptors in the striatum
● Galactorrhea/amenorrhea- linked to
blocking of D2 receptors in the pituitary
● Neuroleptic-induced deficit syndromelinked
to blockade of D2 receptors in the
mesolimbic and mesocortical pathways
● Dizziness, hypotension, and syncope- linked
to inadvertent blockade of alpha 1
adrenergic receptors
Thioridazine Dopamine-Serotonin Receptor Antagonist
Targets positive symptoms of psychosis such as
hallucinations, delusions, aggression, and agitation.
Commonly used for schizophrenic patients who fail to
respond to other antipsychotic medications.

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