1. A 20-kg patient is currently receiving 52 ml/hr of Lactated Ringer's Solution.The clinician
has requested that 2 mg/kg/day of metoclopramide be added tothe bag. Metoclopramide is
available as a 5 mg/ml solution. How many milli- liters do you need to add to a 1 liter bag?
Answer: This is definitely a more complicatedcalculation question, but when broken down it
is not insurmountable.
A 20-kg patient will need 40 mg/day of metoclopramide (20 kg x 2 mg/kg/day)
Since the fluid is being administered at an hourly rate, we need to figure out howmuch
metoclopramide we are administering per hour.
40 mg/day / (24 hr) = 1.7 mg/hr
To determine how much volume of metoclopramide is needed, the following math is
performed:
1.7 mg/hr / (52 ml/hr) x (1000 ml)= 32.6 mg (Notice how the units cancel out.)
32.6 mg / (5 mg/ml) = 6.5 ml
2. What quantity of drug is found in 200 mLs of a 10% solution?
Answer: 20 grams
A 10% solution is equal to 100 mg/mL.The easiest way to remember this conversionis to add a
zero to the percentage. (10%= 100 mg/mL, 15% = 150 mg/mL, etc.)
If 1 mL is equal to 100 mg, then to find out the quantity of drug in 200 mLs, multiply100 mg
X 200 = 20,000 mg.There are 20,000 mg in 200 mLs of a 10% solution.
But none of the choices are 20,000 mg.We need to go one step further anddetermine how
many grams this is.
1 gram is equal to 1,000 mg. We need to divide the milligrams by 1,000.So, 20,000mg / 1,000
= 20 grams.
3. You want to give a pre-surgical dose of antibiotics to your patient.You have a 1 gram vial of
cefoxitin that is reconstituted with 5 mls of sterile water.You wantto give a 20 mg/kg dose to a
25 kg dog. How many mls do you give?
Answer: 2.5mL
Explanation
The resulting concentration of the cefoxitin solution is 1gm/5ml or 200mg/ml.
The desired dose is 20mg/kg x 25 kg = 500 mg200 mg/ml x ml= 500 mg,
Therefore the answer is 2.5 m
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