Must knows on alcohol. Alcohols has high lipid solubility, can pass placental barrier and has teratogenic effect. Fetal alcohol syndrome manifests as mental retardation, congenital heart anomalies, small eye opening, smooth philtrum, thin upper lip, and mid-facial flattening. Alcohols are metabolized using alcohol dehydrogenase pathway and through Microsomal Ethanol Oxidizing System (MEOS). Acetaldehyde metabolism is the final pathway of alcohol through aldehyde dehydrogenase.
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